Most of these grapes are not "protagonists" and are rarely able to stand on their own. The ones that do have great characteristics as protagonist are the ones that eventually become famous nationally and internationally. Just to mention a few and most obvious: Tuscany's Sangiovese, Nebbiolo & Barbera in Piedmont, Aglianico in Campania, Nero d'Avola in Sicily, etc.
Recently we visited Carmignano for our new tour called Wines & Villas. It's a wonderful wine region even if small and fairly unknown and it is the only one that can claim the Cabernet Sauvignon as its own, apparently imported by Medici family members and grown here for centuries making it native-ish.
Hereunder the Medici legislation of 1716, geographically indicating some areas that are still important wine regions today, including Carmignano. This bando (legislation) was a precursor for the present DOCs that obviously also include grape varieties allowed for their production.
When in the area of Carmignano it is mandatory to pay a visit to one of its impressive Medici villas. This is the one in Poggio a Caiano which also hosts a fantastic collection of food paintings "natura morta" including a couple of interesting studies on native grapes in the beginning of the 1700s.